In a rare case, a man living in Germany who had both leukemia and AIDS no longer has any detectable HIV cells in his blood following a stem cell transplant for his leukemia three years ago.
But experts were quick to caution that the case does not have practical implications for the treatment of AIDS worldwide.
As it turns out, the donor for that transplant carried a rare mutation in a gene that increases immunity against the most common form of HIV. First reported in 2009, this follow-up study, published online in the journal Blood, confirms that the recipient patient is still free of both leukemia and HIV three years after the transplant.
But one expert issued strong words of caution in interpreting the finding.
“Our phones have been ringing off the hook,” said Dr. Margaret Fischl, director of the AIDS clinical research unit at the University of Miami Miller School of Medicine. “We are having patients calling us and asking if they can stop their antiretroviral therapy — and the answer is uncategorically no.”
The theory is that if you could wipe out every infected cell you could cure HIV, Fischl said, but this is a unique case.
The patient had intense chemotherapy and radiation, then relapsed and was given a second transplant from the same donor. The donor was unique in that he had a gene that could fight the most common form of HIV. This mutation is seen in about one in every million people, Fischl explained.
“How much did a second transplant contribute to the slow takeover of the donor cells that are resistant to one form of HIV? The extent that that happened is remarkable,” she said.
However, this patient also was infected with another form of HIV as well, Fischl said. “What they are hoping is that the chemotherapy and radiation therapy wiped out that form, too. Could that patient still rebound with HIV in the future? Yes,” she said.
This treatment also carries with it a 30 percent risk of death, Fischl added.
“That he was young and got through it is quite remarkable,” she said. “I would never give this to a healthy patient. I could never justify it. If you use this therapy, 30 percent of your patients could die from the intervention.”
Fischl said the study does present new ways to look for an HIV cure, however. “This is leading to looking at gene therapy in a totally different way,” she said.
“We tell our patients that this was a very particular situation. What made this work was that he got a very rare donor. It opens doors for us, but we are years away from potentially making gene therapy more broadly available,” Fischl said. “It shows us the hurdles we have to get over to get to the cure.”
Back in 2009, Dr. Anthony Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, said the procedure was too expensive and risky to become either common practice or a “cure,” but noted it might help in the development of gene therapies to treat HIV.
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Sorry for the huge review, but I’m really loving the new Zune, and hope this, as well as the excellent reviews some other people have written, will help you decide if it’s the right choice for you.
Zune and iPod: Most people compare the Zune to the Touch, but after seeing how slim and surprisingly small and light it is, I consider it to be a rather unique hybrid that combines qualities of both the Touch and the Nano. It’s very colorful and lovely OLED screen is slightly smaller than the touch screen, but the player itself feels quite a bit smaller and lighter. It weighs about 2/3 as much, and is noticeably smaller in width and height, while being just a hair thicker.
Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.
Apple now has Rhapsody as an app, which is a great start, but it is currently hampered by the inability to store locally on your iPod, and has a dismal 64kbps bit rate. If this changes, then it will somewhat negate this advantage for the Zune, but the 10 songs per month will still be a big plus in Zune Pass’ favor.
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The Zune concentrates on being a Portable Media Player. Not a web browser. Not a game machine. Maybe in the future it’ll do even better in those areas, but for now it’s a fantastic way to organize and listen to your music and videos, and is without peer in that regard. The iPod’s strengths are its web browsing and apps. If those sound more compelling, perhaps it is your best choice.
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The new Zune browser is surprisingly good, but not as good as the iPod’s. It works well, but isn’t as fast as Safari, and has a clunkier interface. If you occasionally plan on using the web browser that’s not an issue, but if you’re planning to browse the web alot from your PMP then the iPod’s larger screen and better browser may be important.
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